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Thanks for the info. on the debugger, too. Much appreciated.
You might want to try resetting Zotero in the second profile to use the default data directory and copying zotero.sqlite (without the 'storage' directory) from the old profile to the new one, in case it has something to do with the presence of the attached PDFs (which could be one reason I couldn't reproduce it).
And something finally clicked with all this from my sysadmin days and I did a disk check with Disk Utility this afternoon, and my hard drive had been corrupted. I let Disk Utility repair my hard drive, and now while there is some lag, there is nothing near as bad as before. I think that might have been the problem.
Sorry to take up so much of your time, but thank you all for your help, and I'll let you know if the problem comes back.
Jon