I don't think you're the standard case here.
And Ctrl/Cmd-I is hardly funky—it's pretty much universal in rich-text editors.
I'm not talking about those, but the other cases
smalls caps that aren't actually even real small caps
will you directly show the formatted text
which might be hard to do in the case of sub/superscript and small caps
Nanosecond electron tunneling between the hemes in cytochrome <i>bo</i><sub>3</sub>
Searching for titles (which I use quite often) requires that you format your search string, too. For example, the title stored as:
Upload image file with the file dialog or by dragging and dropping images onto the dashed region