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• Brilliant, that brought me on the right track. I had not noticed a mention of the cache directory in the threads or knowledge base. But your swift response helped me identify the issue. The /Users/:username:/Library/Cashes folder was owned by the …

  in Your Zotero profile cannot be loaded. It may be missing or inaccessible (Windows) Comment by lennartverhagen June 2, 2018
• Hi all, After updating to Zotero 5.0 on macOS 10.13.4 I too got the dreaded "*Profile missing* Your Zotero profile cannot be loaded. It may be missing or inaccessible." The profile folder at ~/Library/Application Support/Zotero has the usual (and …

  in Your Zotero profile cannot be loaded. It may be missing or inaccessible (Windows) Comment by lennartverhagen May 31, 2018