Download issue

I have downloaded the latest version of Zotero. I have opened my desktop and cloud versions of Zotero. And no matter what I do, I get an error message for the pdf/document I am trying to push to Zotero. It says "This item could not be saved because Zotero is not open or is unreachable. Please open Zotero and try again."
What am I doing wrong. Have never had issues
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