Is there a default locale for xml:lang="en"?

I've been reading through a few CSL formats trying to get a hang of it, and I noticed that MLA 8th edition uses the "en" locale code. It seems that this may be ambiguous because some terms in locales-en-US.xml, such as date, open-quote, etc., are defined differently from those in locales-en-GB.xml.

Question: If a CSL style uses the "en" locale code, which locale file does it use: locales-en-US.xml or locales-en-GB.xml? Is there a default locale for "en"?
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