PDFs and Tablets

What are the advantages (if any) of reading and annotating PDFs on a Tablet over using a PDF viewer on a desktop or laptop?

Are tablet screens easier on the eye than computer screens for long periods of reading? Are certain tablets better than others? I heard a version of Kindle used E-Ink which was supposed to reduce eye-strain and feel like a book. Is that still the case? Is a Kindle screen any better than an Ipad screen or mac display?

Do tablets have features that make annotation more natural than on a computer, like working with pen and paper?
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