The lack of a proper error message here is a bug that's been fixed for the next version, but this occurs when Zotero can't find the Zotero data directory in its configured location.
Either because the custom data directory is no longer where it was — you can try setting it again — or because there's a problem with it, such as security software interfering with Zotero's ability to write to it.
If so, see
https://www.zotero.org/support/reporting_bugs#reporting_startup_errors
I want to send you screen shot
why can not work when I customize the data directory location?