Syncing PDF files with Zotero Storage across multiple computers

Can I confidently work on an attached PDF document on my home computer, sync it manually if necessary (or count on auto-syncing), got to my office (15 minutes away), continue working on the file on my office computer, and so on back and forth between home and office without ever having to close and re-open the files? Or do I in fact need to close a PDF file in one location and re-open it in the other? I'm sure the answer is there on the forum somewhere, but I cannot easily find a post that answers my question explicitly.
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