Do you mean that it's crashing? As in closing completely, or are you getting an error message in Zotero? How are you disabling plugins if it's crashing at startup?
What OS? Can you provide any sort of crash report?
Make sure you're using the latest version of Zotero from the download page.
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What OS? Can you provide any sort of crash report?
Make sure you're using the latest version of Zotero from the download page.