Cannot open Zotero

I get always the following message, anyone knows what to do? Thanx, Remo

Error: Error(s) encountered during statement execution: disk I/O error [QUERY: SELECT COUNT(*) > 0 FROM itemData WHERE fieldID NOT IN (SELECT fieldID FROM itemTypeFieldsCombined WHERE itemTypeID=(SELECT itemTypeID FROM items WHERE itemID=itemData.itemID))] [PARAMS: ] [ERROR: disk I/O error]
Zotero.DBConnection.prototype.valueQueryAsync@chrome://zotero/content/xpcom/db.js:731:13
From previous event:
ZoteroService@file:///C:/Program%20Files%20(x86)/Zotero/components/zotero-service.js:348:7
@chrome://zotero/content/include.js:4:14
  • dstillman Zotero Team
    This is a generic storage I/O error — there's no way for us to tell you specifically what the problem is. The most common cause is having your Zotero data directory on a network filesystem or in a cloud storage folder (where it should never be), but it could also be due to an actual physical problem with your disk or due to security software interfering with Zotero's ability to access the disk.
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