Is it possible to write comments in a PDF file using LaTeX syntax?

Hello,

I just wonder whether it is possible to write comments in a PDF file using LaTeX syntax and display the results. It is probably not a very common demand, but sometimes I may want to comment on a PDF file with some mathematical expressions. If I write in plain characters, it is not so easy to read.
Is it possible to do so in Zotero or any other programs?

Thanks for any help.
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