Zotero lagging

Hi,
I have a problem with the bibliography refresh of Zotero.
I have a Word document +/- 450pg long (Word Office 16), more than 500 citations and Zotero 6.0.36.
The problem is when I want to refresh my bibliography, it processes during more than one night and I have to stop it manually to see what happened. He actualized some references but not all.
What can I do ? Is this time normal ? How long do I have to wait to be sure all the references are actualized ?
Do you have a solution to spend less time ?
Thank you for your quick help
Julie
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