Word shows a message that plugins are disabled

[Split from Word: buttons for Zotero citing are not working]

Hi,
it seems like I have the same issue. The Buttons are visible but unresponsive and Word shows a message that plugins are disabled. The startup-folder is trusted but Word 2021 will not run zotero as it assumes the certificate is outdated. Word 2016 works fine.
I tried to reinstall the plugin both manually and automatically a few times.
Any idea how I can solve the issue?

Thanks in advance
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