Overly large libraries?

I use my unlimited storage capacity liberally (I subscribe to the unlimited data option), and I wonder if having 22,000 items makes my library unwieldy. How do other people handle large libraries? I use the library for my own research on many different sub-topics in my field as well as for teaching and advising graduate students, so I can't envision dividing it into smaller libraries: everything is related to everything else.
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