Upgrade error can't open Zotero now

Upgrading to 2.0 got error message 472577949 and now can't open Zotero at all.
  • This is in Windows XP 5.1
  • [JavaScript Error: "[Exception... "Component returned failure code: 0x80520015 (NS_ERROR_FILE_ACCESS_DENIED) [nsIFileOutputStream.init]" nsresult: "0x80520015 (NS_ERROR_FILE_ACCESS_DENIED)" location: "JS frame :: chrome://zotero/content/xpcom/file.js :: putContents :: line 160" data: no]" {file: "chrome://zotero/content/upgrade.xul" line: 53}]"
    Try restarting your computer.
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