[JavaScript Error: "Unix error 22 during operation setDates on file /home/[…]/Zotero/storage/HMWJ9ETU/[…].pdf (Invalid argument)" {file: "(unknown module)" line: 0}]

[JavaScript Error: "Could not open connection to /home/[…]/Zotero/zotero.sqlite: 2153971713" {file: "resource://gre/modules/Sqlite.jsm" line: 945}]

Something on your system — likely some sort of security software — is preventing Zotero from writing to files within the Zotero data directory properly. The first error is EINVAL and the second error is NS_ERROR_STORAGE_BUSY, but that's about all we can tell you.