Zotero 5.0 failed to open

Upgraded to the zotero version Zotero-5.0.21 and throws this error message:
LSOpenURLsWithRole() failed with error -10810 for the file /Applications/Zotero.app.
After executing this command:
open /Applications/Zotero.app/

I have an old mac osx 10.6.8 everything was working with the previous version.
This can be solved?

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