"Close Zotero. Only one copy of Zotero can be opened at a time"

Anytime I try to open Zotero I get the message "Close Zotero. Only one copy of Zotero can be opened at a time"

I have restarted Safari. Restarted my computer. Closed out of all of my applications. Uninstalled and reinstalled Zotero on Safari. Uninstalled and reinstalled on Firefox. I get the message again every time I try something different.
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