Problem starting up

I am getting the following error when trying to startup zotero.

Error: [Exception... "Component returned failure code: 0x8052000e (NS_ERROR_FILE_IS_LOCKED) [mozIStorageService.openDatabase]" nsresult: "0x8052000e (NS_ERROR_FILE_IS_LOCKED)" location: "JS frame :: chrome://zotero/content/xpcom/db.js :: anonymous :: line 799" data: no]
Source File: chrome://zotero/content/xpcom/zotero.js
Line: 220

Note that I am using zotero on a portable hard drive. The "master" is kept on my desktop at work. I sync to the portable when I go home. The idea is that I would like to be able to use zotero at home with the database and re-sync the next time I am in the office. It worked for a while and then, for some reason, the above error started arising. Note that it looks like the permissions are all 777 on the portable. Also, the work Mac is Intel while the one at home is PPC in case that makes a difference.

Thanks for the help,

Eric

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